An appraisal of immunonutrition for clinical nutritional support with a systematic review of English and Chinese documents / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 552-558, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-278139
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy, safty and economical values of immunonutrition for clinical nutritional support.</p><p><b>METHODS</b>The following electronic databases were searched Chinese Biomedicine database (CBM), MEDLINE, EMBASE, Cochrane Library and SCI. Data were extracted by two reviewers. RevMan 4.1 was applied for statistical analysis.</p><p><b>RESULTS</b>Seventeen randomised trials comparing the use of immunonutrition which comprises nucleotides, omega-3 fatty acids and arginine with standard enteral nutrition in surgical, trauma/burn and critical illness patients. Combined analysis indicated that the use of immunonutrition decreased infectious events (pooled OR was 0.51, 95%CI [0.38, 0.67], P = 0.00001), length of hospitalization, and the cost. In sensitivity analysis for mortality, we found an increased tendency in immunonutrition (pooled OR was 1.94, 95%CI [1.05, 3.57], P = 0.03). Further sub-group analysis indicated that the effects of immunonutrition were various in different patient types.</p><p><b>CONCLUSIONS</b>Immunonutrition is associated with decreasing of infectious rates, length of hospitalization and cost in selective operation patients. But current evidence can't affirm the role of immunonutrition on critical illness patients. Further studies are urgently needed to clarify the reliability of immunonutrition in this group.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Arginina
/
Alimentos Formulados
/
Ácidos Graxos Ômega-3
/
Avaliação de Resultados em Cuidados de Saúde
/
Estado Terminal
/
Nutrição Enteral
/
Apoio Nutricional
/
Glutamina
/
Sistema Imunitário
/
Métodos
Tipo de estudo:
Ensaio Clínico Controlado
/
Revisões Sistemáticas Avaliadas
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2002
Tipo de documento:
Artigo
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