The efficacy of alendronate in the prevention and treatment of postmenopausal osteoporosis / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 306-309, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-278176
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effectiveness of alendronate Chinese national product in the prevention and treatment of postmenopausal osteoporosis.</p><p><b>METHODS</b>The 56 postmenopausal women with osteopenia or osteoporosis were randomly divided into two groups treated with alendronate 10 mg/d (28 cases) orally and placebo (28 cases), for 6 months. All subjects received 600 mg/d of calcium carbonate and vitamin D 1,000 U/d. Bone mineral density (BMD) of the lumbar spine, femoral neck, trochanter and Ward's triangle were measured by dual energy X-ray absorptiometry as well as the markers of bone turnover were analysed at the beginning and the end of the study.</p><p><b>RESULTS</b>The results showed that lumbar spine BMD increased by 5% in the alendronate group (P < 0.01), but decreased in BMD of the lumbar spine and femur in the placebo group (P < 0.05) after 6 months of treatment. In the alendronate group the marker of bone resorption and bone formation were significantly decreased after alendronate therapy. There were no change in placebo group.</p><p><b>CONCLUSIONS</b>Alendronate (Chinese national product) is effective in reducing bone turnover and promoting bone mass of postmenopausal osteoporosis.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Absorciometria de Fóton
/
Densidade Óssea
/
Osteoporose Pós-Menopausa
/
Alendronato
/
Usos Terapêuticos
/
Tratamento Farmacológico
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Idoso
/
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2002
Tipo de documento:
Artigo
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