Design and synthesis of 3'-methyl-furanonucleosides and their anti-tumor activities / 药学学报
Acta Pharmaceutica Sinica
;
(12): 747-753, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-278188
ABSTRACT
Taking 3'-Me-Ado (3'-methyladenosine) and Cladribine as the leading compounds, seventeen 3'-C-methyl-furanonucleosides were designed and synthesized. All the structures were confirmed by 1H NMR and MS. The target compounds were tested in vitro against human pulmonary carcinoma A549, human colon carcinoma LOVO and human leukemia CEM by MTT assay. The results showed that these compounds possessed moderate cytotoxicities.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Ensaios de Seleção de Medicamentos Antitumorais
/
Estrutura Molecular
/
Adenosina
/
Cladribina
/
Linhagem Celular Tumoral
/
Antineoplásicos
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2009
Tipo de documento:
Artigo
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