Antifungal active triterpene glycosides from sea cucumber Holothuria scabra / 药学学报
Acta Pharmaceutica Sinica
;
(12): 620-624, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-278209
ABSTRACT
To study the new antifungal active triterpene glycosides of sea cucumber Holothuria scabra. Triterpene glycosides from Holothuria scabra were separated and purified by silica gel chromatography, reversed-phase silica gel chromatography and RP-HPLC. Their structures were elucidated on the basis of spectral data and chemical evidence. Three triterpene glycosides were identified as scabraside A (1), echinoidea A (2) and holothurin A1 (3). Scabraside A (1) is a new triterpene glycoside, and compounds 2 and 3 were isolated from Holothuria scabra for the first time. They showed antifungal activities (1 < or = MIC80 < or = 16 microg mL(-1)).
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Triterpenos
/
Estrutura Molecular
/
Química
/
Holothuria
/
Glicosídeos
/
Holoturina
/
Antifúngicos
Limite:
Animais
Idioma:
Inglês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2009
Tipo de documento:
Artigo
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