Role of PKCbeta in the malignant tumors and enzastaurin, a PKCbeta inhibitor / 药学学报
Acta Pharmaceutica Sinica
;
(12): 449-455, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-278240
ABSTRACT
Protein kinase C beta (PKCbeta) is a multifunctional serine/threonine protein kinase, which plays an important role in many cell signaling pathways. PKCbeta takes part in multiple physiological processes, including regulation of the cell cycle, differentiation, proliferation, apoptosis and angiogenesis. Increased PKCbeta activity has been observed in many human cancers, such as colon, breast and haematological malignancies. At present, Enzastaurin is mostly studied in preclinical and clinical studies, which is a selective PKCbeta inhibitor. This review focuses on the functional properties of PKCbeta, its role played in tumors and Enzastaurin.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Proteína Quinase C
/
Química
/
Ensaios Clínicos como Assunto
/
Linhagem Celular Tumoral
/
Usos Terapêuticos
/
Inibidores de Proteínas Quinases
/
Proliferação de Células
/
Tratamento Farmacológico
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2009
Tipo de documento:
Artigo
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