Synthesis, solubility, lipids-lowering and liver-protection activities of sulfonated formononetin / 药学学报
Acta Pharmaceutica Sinica
;
(12): 386-389, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-278252
ABSTRACT
A water-soluble compound, sodium formononetin-3'-sulfonate with good lipid-lowering and liver-protection activities was synthesized. It was synthesized by sulfonation reaction, and its structure was characterized by IR, NMR and elemental analyses. The solubility of sodium formononetin-3'-sulfonate in water and n-octanol/water partition coefficient were determined by UV spectrophotometry. The lipid-lowering and liver-protection activities of sodium formononetin-3'-sulfonate were tested by using rat's high fat model induce by feeding with high fat food. The results showed that sodium formononetin-3'-sulfonate not only had favorable water, solubility but also had good lipid-lowering and liver-protection activities.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Aspartato Aminotransferases
/
Solubilidade
/
Triglicerídeos
/
Sangue
/
Estrutura Molecular
/
Química
/
Tecido Adiposo
/
Colesterol
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2009
Tipo de documento:
Artigo
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