Hepatobiliary transport of glutathione and its role in cholestasis / 药学学报
Acta Pharmaceutica Sinica
;
(12): 327-332, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-278262
ABSTRACT
Glutathione is a tripeptide comprised by L-glutamate, L-cysteine, and glycine, that serves antioxygenation and deintoxication functions within the cell. Recent study has found that glutathione is the main driving force for bile salt-independent bile flow, impaired biliary excretion of glutathione can lead to cholestasis. This review focuses on hepatobiliary transport of glutathione and its role in cholestasis. Based on the evidence of choleretic effect of glutathione, enhancement of biliary excretion of glutathione may be a good strategy for prevention and treatment of cholestasis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Faloidina
/
Ácido Ursodesoxicólico
/
Transporte Biológico
/
Colestase
/
Proteínas Associadas à Resistência a Múltiplos Medicamentos
/
Usos Terapêuticos
/
Estrogênios
/
Genética
/
Glutationa
/
Icterícia Idiopática Crônica
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2009
Tipo de documento:
Artigo
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