Comparative pharmacophore analysis of dual dopamine D2/5-HT(2A) receptor antagonists / 药学学报
Acta Pharmaceutica Sinica
;
(12): 314-320, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-278264
ABSTRACT
Dual dopamine D2/5-HT2A receptor antagonists have potent activity and are referred to atypical antipsychotics due to their lower propensity to elicit EPS and their moderate efficacy toward negative symptoms. However, an on-going challenge in developing atypical antipsychotics drugs is to maintain the favorable profiles and avoid of cardiovascular risk. In this paper, comparative pharmacophore analysis of dual dopamine D2/5-HT2A receptor antagonists, hERG K+ channel blockers, and alA adrenoceptor antagonists is carried out, and the results could give some insight into multi-target drug design.
Texto completo:
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Relação Estrutura-Atividade
/
Desenho de Fármacos
/
Estrutura Molecular
/
Química
/
Sistemas de Liberação de Medicamentos
/
Receptores de Dopamina D2
/
Receptores Adrenérgicos alfa 1
/
Receptor 5-HT2A de Serotonina
/
Canais de Potássio Éter-A-Go-Go
/
Antagonistas de Receptores Adrenérgicos alfa 1
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2009
Tipo de documento:
Artigo
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