Thoughts and experimental exploration on pharmacokinetic study of herbal medicines with multiple-components and targets / 药学学报
Acta Pharmaceutica Sinica
;
(12): 270-275, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-278271
ABSTRACT
The pharmacokinetic research of traditional Chinese medicines (TMC) is an inalienable part of the chain of TCM modernization and plays an important role in the TCM novel drug development. However, the researching method and system that is consistent with the specific characteristics of TCM, i.e., multiple-components and targets, is still lacking. Furthermore, the current understanding of the critical scientific questions of TCM pharmacokinetics remains still unclear. This review makes a brief summary of our recent developments on the pharmacokinetic exploration of TCMs, mainly including integral pharmacokinetic study of multiple components, herbalome analysis both in vitro and in vivo, mechanism based compatibility study for herbal components interactions, and the representative pharmacokinetic study for single herbal compound. Furthermore, the critical scientific questions of TCM pharmacokinetics are discussed based on understanding the requirements of novel drug developments from TCM.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plantas Medicinais
/
Medicamentos de Ervas Chinesas
/
Farmacocinética
/
Química
/
Relação Quantitativa Estrutura-Atividade
/
Análise de Componente Principal
/
Combinação de Medicamentos
/
Interações Medicamentosas
/
Sinergismo Farmacológico
/
Medicina Tradicional Chinesa
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2009
Tipo de documento:
Artigo
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