Identification of a novel HLA allele, HLA-B*35:03:07, by sequencing-based typing / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1010-1013, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-278446
ABSTRACT
This study was purposed to analyze and identify a novel HLA allele in Chinese population. A new HLA-B allele which is closely related to HLA-B*350301 was initially detected by PCR-SSOP, then DNA sequencing was performed to identify the difference between the novel allele and HLA-B*350301 allele. The result showed that the sequence of the new allele was different from all other known sequence. It differs from the closest matching HLA-B*350301 by a single substitution at position 387 C→G in exon 3, no resulting in amino acid change. It is concluded that this allele is a novel one and has been officially named B*350307 by the WHO Nomenclature Committee.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antígenos HLA-B
/
Análise de Sequência de DNA
/
Povo Asiático
/
Alelos
/
Genética
Limite:
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2012
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS