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Histologic detection of cytomegalovirus and its application in gastrointestinal cytomegalovirus infection / 中华病理学杂志
Chinese Journal of Pathology ; (12): 170-174, 2016.
Artigo em Chinês | WPRIM | ID: wpr-278489
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinical and pathologic features of gastrointestinal cytomegalovirus (CMV) disease, and the histological detection of CMV.</p><p><b>METHODS</b>Forty-one gastrointestinal tissues were obtained from 35 patients suspected for gastrointestinal CMV disease. The pathologic changes of these specimens were evaluated by immunohistochemistry and in situ hybridization for CMV, and these were compared to serologic detection methods.</p><p><b>RESULTS</b>CMV was detected in 23/41 tissues. There were 32 serologic CMV DNA tests at the time of biopsies or operations. Compared with histological detection, the sensitivity and specificity of serologic CMV DNA tests were 73.7% and 69.2% respectively.</p><p><b>CONCLUSIONS</b>Gastrointestinal histological detection of CMV has important clinical application. HE staining combined with immunohistochemistry and/or in situ hybridization detection is a reliable method to detect CMV.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Virologia / Biópsia / Imuno-Histoquímica / Hibridização In Situ / Infecções por Citomegalovirus / Citomegalovirus / Diagnóstico / Gastroenteropatias Tipo de estudo: Estudo diagnóstico Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Pathology Ano de publicação: 2016 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Virologia / Biópsia / Imuno-Histoquímica / Hibridização In Situ / Infecções por Citomegalovirus / Citomegalovirus / Diagnóstico / Gastroenteropatias Tipo de estudo: Estudo diagnóstico Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Pathology Ano de publicação: 2016 Tipo de documento: Artigo