Identification of known and novel PTCH mutations in both syndromic and non-syndromic keratocystic odontogenic tumors / 国际口腔科学杂志·英文版
International Journal of Oral Science
;
(4): 34-38, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-278974
ABSTRACT
<p><b>AIM</b>To clarify the role of PTCH in patients with NBCCS-related and non-sydromic keratocystic odontogenic tumors.</p><p><b>METHODOLOGY</b>Mutation analysis was undertaken in 8 sporadic and 4 NBCCS-associated KCOTs.</p><p><b>RESULTS</b>Four novel and two known mutations were identified in 2 sporadic and 3 syndromic cases, two of which being germline mutations (c.2179delT, c.2824delC) and 4 somatic mutations (c.3162dupG, c.1362-1374dup, c.1012 C>T, c.403C>T).</p><p><b>CONCLUSION</b>Our findings suggest that defects of PTCH are associated with the pathogenesis of syndromic as well as a subset of non-syndromic KCOTs.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Síndrome
/
Treonina
/
Timina
/
Síndrome do Nevo Basocelular
/
Tumores Odontogênicos
/
Éxons
/
Mutação da Fase de Leitura
/
Cromatografia Líquida de Alta Pressão
/
Sequência de Aminoácidos
/
Deleção de Sequência
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
International Journal of Oral Science
Ano de publicação:
2009
Tipo de documento:
Artigo
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