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The relationship of cervical cancer with pathogen infectious, cytokine and Se / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology ; (6): 179-183, 2002.
Artigo em Chinês | WPRIM | ID: wpr-278983
ABSTRACT
<p><b>BACKGROUND</b>To identify the relationship of cervical cancer with pathogen infectious, cytokine and Se.</p><p><b>METHODS</b>On the one hand regarded tissues of the carcinoma of the uterine cervix with 195 cases as the experimental group and ordinary cervical tissues with 75 cases as the control group. Polymerase chain reaction (PCR) to detect them. On the other hand applied ELISA to detect cytokine IL-2R, TNF and fluorescent luminosity technique to detect element Se in the serums.</p><p><b>RESULTS</b>In the experimental group those infected pathogen were 166 cases (85.1%), In all of pathogen HPV 16,18,35 type were 60 cases (30.8%), HSV 2 were 60 cases (30.8%), While those ordinary tissues infected pathogen were 15 cases (20 0%),in the contrast group. HPV 16,18,35 type and HSV 2 mere 4.0% and 6.7% respectively,(P<0.001). In the serums of effective 62 experimental objects IL-2R (x=356.44 U/ml) and TNF (x=373.48 pg/ml) were much high than them in the serums of effective 36 contrast objects (P<0.001). But Se (x=0.058 mg/ml) was lower than it in the serums of contrast objects (P<0.05).</p><p><b>CONCLUSIONS</b>The occurrence of carcinoma of the uterine cervix is closely connected with infection of HPV 16,18,35 and HSV2, high level of cellular factors IL-2R, TNF and low level of element Se.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Selênio / Infecções Tumorais por Vírus / Virologia / Sangue / Receptores de Interleucina-2 / Neoplasias do Colo do Útero / Reação em Cadeia da Polimerase / Fator de Necrose Tumoral alfa / Infecções por Papillomavirus / Herpes Simples Tipo de estudo: Estudo prognóstico Limite: Feminino / Humanos Idioma: Chinês Revista: Chinese Journal of Experimental and Clinical Virology Ano de publicação: 2002 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Selênio / Infecções Tumorais por Vírus / Virologia / Sangue / Receptores de Interleucina-2 / Neoplasias do Colo do Útero / Reação em Cadeia da Polimerase / Fator de Necrose Tumoral alfa / Infecções por Papillomavirus / Herpes Simples Tipo de estudo: Estudo prognóstico Limite: Feminino / Humanos Idioma: Chinês Revista: Chinese Journal of Experimental and Clinical Virology Ano de publicação: 2002 Tipo de documento: Artigo