Roles of follicular helper T cells and follicular regulatory T cells in pathogenesis of Henoch-Schönlein purpura in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1084-1087, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-278993
ABSTRACT
<p><b>OBJECTIVE</b>To study the roles of follicular helper T (Tfh) cells and follicular regulatory T (Tfr) cells in the pathogenesis of Henoch-Schönlein purpura (HSP) in children.</p><p><b>METHODS</b>Peripheral blood samples were collected from 40 HSP children and 25 healthy controls. The percentages of Tfh and Tfr cells were measured by flow cytometry; the mRNA expression levels of Bcl-6, c-MAF, Blimp-1, and PD-1 in peripheral blood were measured by real-time polymerase chain reaction.</p><p><b>RESULTS</b>Compared with the controls, the children with HSP had significantly increased percentage of Tfh cells and Tfh/Tfr ratio but a significantly reduced percentage of Tfr cells in the peripheral blood (P<0.05). Compared with the controls, the children with HSP had significantly increased mRNA expression of Bcl-6 and c-MAF but significantly reduced mRNA expression of Blimp-1 in CD4+ T cells (P<0.05), and had significantly increased mRNA expression of PD-1 but significantly reduced mRNA expression of Blimp-1 in CD4+CD25+ regulatory T cells (P<0.05).</p><p><b>CONCLUSIONS</b>Abnormal percentages of Tfh and Tfr cells may be involved in the pathogenesis of HSP in children, and over-expression of Bcl-6, c-MAF, and PD-1 mRNA and inhibited expression of Blimp-1 mRNA may be considered as important reasons for abnormal percentages of Tfh and Tfr cells.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Vasculite por IgA
/
Linfócitos T Reguladores
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Linfócitos T Auxiliares-Indutores
/
Proteínas de Ligação a DNA
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Alergia e Imunologia
/
Proteínas Proto-Oncogênicas c-maf
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Proteínas Proto-Oncogênicas c-bcl-6
/
Receptor de Morte Celular Programada 1
/
Genética
Tipo de estudo:
Estudo de etiologia
Limite:
Adolescente
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2015
Tipo de documento:
Artigo
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