Comparison of total phenol of magnolia solid dispersion prepared by different methods / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 4400-4405, 2015.
Article
em Zh
| WPRIM
| ID: wpr-279226
Biblioteca responsável:
WPRO
ABSTRACT
To compare the difference of total phenol of magnolia solid dispersion prepared by different methods. Hot melt extrusion, solvent evaporation method, and fusion-cooling method were used to prepare total phenol of Magnolia accessory solid dispersion, Plastone S-630 and HPC. The drug dispersion state in the prepared solid dispersion was evaluated with DSC and X-ray diffraction; FT-IR method was used to analyze the possible connections between drug and accessories. Finally, accelerated stability-in vivo dissolution test was use to compare the stability differences between these three processes. The results of DSC and X-ray diffraction showed that all of the drug in solid dispersion processed by three processes can exist in amorphous form; FT-IR results also could not distinguish the difference between the three processes; accelerated stability-in vivo dissolution test showed the stability of solid dispersion prepared by HPC was better than Plastone S-630, and the same kinds of materials solid dispersion prepared by hot melt extrusion showed a better stability than the other two processes.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Difração de Raios X
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Medicamentos de Ervas Chinesas
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Química
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Química Farmacêutica
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Espectroscopia de Infravermelho com Transformada de Fourier
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Fenol
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Magnolia
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Métodos
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2015
Tipo de documento:
Article