Effect of ginsenoside total saponinon on regulation of P450 of livers of rats after γ-ray irradiation / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 4037-4043, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-279288
ABSTRACT
Effect of ginsenoside total saponin (GTS) on the regulation of P450 of livers of rats after γ-ray irradiation was studied. Rats were irradiated by the ⁶⁰Coγ-ray for one-time dose of 5.5 Gy, dose rate of 117.1-119.2 cGy. The cocktail probe, qPCR and Western blot were used to detect expression of enzymatic activites, mRNA and protein of rats. Contrasted with blank group, expression of CYP1A2, 2B1, 2E1, 3A4 of irradiation group showed a up-regulated (P < 0.05). Contrasted with irradiation group, exprression of CYP1A2, 2B1, 2E1, 3A4 of GTS group showed a downward trend. GTS had negative agonistic action against expression of P450 of rats by irradiatied.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Efeitos da Radiação
/
Microssomos Hepáticos
/
Medicamentos de Ervas Chinesas
/
Química
/
Ratos Wistar
/
Sistema Enzimático do Citocromo P-450
/
Ginsenosídeos
/
Raios gama
/
Genética
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2015
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS