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The sinus node itself also plays a role in heart rate slowing down during postnatal development / 生理学报
Acta Physiologica Sinica ; (6): 282-286, 2002.
Artigo em Chinês | WPRIM | ID: wpr-279297
ABSTRACT
The slowing down mechanism of heart rate during growth of the body after birth was studied in isolated rabbit heart and sinus node (SN) preparation with Langendorff perfusion method, conventional microelectrode recording and perforated patch for recording pacemaker current I(f). The radioimmunoassay was also used to measure the concentration of cAMP within SN cells. The results indicate that without the influence of nervous and humoral factors, the spontaneous heart rate would also become slower as the rabbit grew older, which is due to the decrease of spontaneous depolarized rate of phase 4 in SN cells. The negative directed shift of the threshold potential of I(f) and the decrease in cAMP concentration within SN cells may be responsible for the phenomenon. The results obtained suggest that besides the nervous and humoral factors which influence the heart rate, the changes in automaticity of SN cell itself may take part in the slowing down process as the body grows up.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Perfusão / Fisiologia / Nó Sinoatrial / Técnicas In Vitro / AMP Cíclico / Frequência Cardíaca / Microeletrodos Limite: Animais Idioma: Chinês Revista: Acta Physiologica Sinica Ano de publicação: 2002 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Perfusão / Fisiologia / Nó Sinoatrial / Técnicas In Vitro / AMP Cíclico / Frequência Cardíaca / Microeletrodos Limite: Animais Idioma: Chinês Revista: Acta Physiologica Sinica Ano de publicação: 2002 Tipo de documento: Artigo