Effect of angiotensin II on potassium channels of ischemic ventricular myocytes of the guinea pig / 生理学报
Acta Physiologica Sinica
;
(6): 149-153, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-279321
ABSTRACT
The experiments were carried out on guinea pig isolated ventricular myocytes by using whole-cell patch clamp. The effects of angiotensin II (Ang II) on potassium ion channels of acute ischemic myocytes were observed. Whole-cell patch clamp recordings showed that physiological potassium current, including delayed rectifier potassium current and inward rectifier potassium current were inhibited under the condition of simulated ischemia, and then further inhibited by treatment with Ang II. ATP-sensitive potassium currents were increased under simulated ischemia and were further enhanced by Ang II treatment.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Fisiologia
/
Angiotensina II
/
Canais de Potássio
/
Células Cultivadas
/
Isquemia Miocárdica
/
Biologia Celular
/
Miócitos Cardíacos
/
Cobaias
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2002
Tipo de documento:
Artigo
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