Influence of regulatory peptides on the secretion of interleukins from bronchial epithelial cells of the rabbit / 生理学报
Acta Physiologica Sinica
;
(6): 107-110, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-279330
ABSTRACT
To explore the role of regulatory peptides in the secretion of bronchial epithelial cells (BECs), we observed the effects of four peptides, i.e.vasoactive intestinal peptide (VIP), epidermal growth factor (EGF), endothelin-1 (ET-1), and calcitonin gene-related peptide (CGRP), on the secretion of ILs from unstimulated or O3-stressed BECs. The results of the experiments showed that VIP exerted an inhibitory effect on the secretion of IL-1 and IL-8 from unstimulated and O3-stressed BECs, VIP also decreased the secretion of IL-5 from O3-stressed BECs; EGF promoted secretion of IL-1 and IL-8 from unstimulated BECs, but decreased the secretion of ILs from O3-stressed BECs; ET-1 and CGRP enhanced the secretion of IL-1, IL-5, and IL-8 from unstimlated BECs, CGRP also increased the secretion of ILs from O3-stressed BECs. The results obtained demonstrate that intrapulmonary regulatory peptides modulate the secretion of ILs from BECs, and may play an important part in transduction of inflammatory signals.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Brônquios
/
Peptídeo Intestinal Vasoativo
/
Peptídeo Relacionado com Gene de Calcitonina
/
Células Cultivadas
/
Interleucinas
/
Endotelina-1
/
Secreções Corporais
/
Biologia Celular
/
Fator de Crescimento Epidérmico
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2002
Tipo de documento:
Artigo
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