Alkaloids from Senecio scandens / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2572-2575, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-279398
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the alkaloids from Senecio scandens.</p><p><b>METHOD</b>Compounds were isolated with silica gel and Sephadex LH-20 column chromatography and their structures were determined by spectral analysis and chemical evidence. The hepatic cytotoxicity of isolated compounds was tested by MTT method in vitro.</p><p><b>RESULT</b>Six alkaloids were obtained and identified as adonifoline (1), 7-angeloylturneforcidine (2), hordenine (3), 1, 3, 6, 6-tetramethyl-5, 6, 7, 8-tetrahydro-isoquinolin-8-one (4), 4-(pyrrolidin-2-one) -phenyl acetic acid (5), (4-pyrrolidinophenyl) acetic acid (6).</p><p><b>CONCLUSION</b>Compound 6 is a new natural product, compounds 3, 4 were obtained from the genus Senecio for the first time, compounds 2, 5 were obtained from this plant for the first time. Compound 1 showed significant growth inhibitory effect against hepatocyte at 100 micromol x L(-1).</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Alcaloides de Pirrolizidina
/
Senécio
/
Tiramina
/
Células Cultivadas
/
Química
/
Cromatografia Líquida de Alta Pressão
/
Dextranos
/
Ácido Acético
/
Hepatócitos
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2010
Tipo de documento:
Artigo
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