Preparation and characterization of non-ionic surfactant vesicle of cantharidin / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the preparation of cantharidin entrapped non-ionic surfactant vesicle (noisome)and evaluate its quality.</p><p><b>METHOD</b>The niosome loaded with cantharidin was prepared using injection method by non-ionic surfactants as the carrier. An centrifugation separation method and HPLC analysis method of the cantharidin were established to detect the entrapment efficiency. The optimum preparation technology was established by a orthogonal experiment. The morphology, and particle size were studied to evaluate the preparation.</p><p><b>RESULT</b>The average size of niosomes were (209. 8 +/- 0.5) nm. The entrapment efficiency of the CTD-NS was (27.5% +/- 2.0%) and Zeta potential was (41.5 +/- 0.65) mV.</p><p><b>CONCLUSION</b>The preparation of cantharidin noisome by TweenA and SpanB is practicable and successful. These experiments can be the basement of developing targeting drug delivery system.</p>