Chemical constituents of bear bile / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the chemical constituents of bear bile.</p><p><b>METHOD</b>The compounds were isolated by repeated column HP20 macroporous adsorption resin, Sephadex LH-20, ODS and silica gel as packing materials. The structures were identified on the basis of extensive spectroscopic data analysis and by comparison of their spectral data reported.</p><p><b>RESULT</b>Nine compounds were identified as 4',7-dihydroxyisoflavone (1), 4',7-dihydroxy-6-methoxyisoflavone (2), 4',6,7-trihydroxyisoflavone (3), 4'-methoxy-7-hydroxyisoflavone (4), tauroursodeoxycholic acid (5), taurochenodeoxycholic acid (6), ursodeoxycholic acid (7), chenodeoxycholic acid (8), cholesterol (9).</p><p><b>CONCLUSION</b>Compounds 1-4 were separated from bear bile for the first time.</p>