A study on expression of basic fibroblast growth factors in periodontal tissue following orthodontic tooth movement associated with low power laser irradiation / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>The purpose of this study was to investigate the effects of low power laser on basic fibroblast growth factors (bFGF) expression in periodontal tissue during tooth movement.</p><p><b>METHODS</b>18 white rabbits were randomly divided into 6 groups with 3 rabbits in each group, including groups of 1, 3, 5, 7, 14 and 21 days. Under an anesthesia condition by 2% pentobarbital sodium, the stainless coil springs were fixed between the first maxillary molar and the incisor producing the force of 80 g. The right side of maxilla was considered as the experimental group under the irradiation of low power laser with the left side as the control groups. The expression of bFGF was investigated half-quantitatively through immunohistochemical analysis.</p><p><b>RESULTS</b>The expression of bFGF in periodontal tissue with irradiation of low power laser was higher than the control side. There were significant differences among the 5, 7, and 14 day groups. In the tension area of the experimental side, the expression of bFGF in the osteoblastic surface of alveolar bone was characteristically greater than that of the control side.</p><p><b>CONCLUSION</b>The laser of low power promotes the expression of bFGF in the periodontal tissue and alveolar bone remodeling.</p>