Relationship between macrophages and erythropoiesis / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 94-99, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-279891
ABSTRACT
Macrophages have two major roles in regulating the dynamic equilibrium in erythropoiesis, promoting the differentiation and maturation of nucleated red blood cells into reticulocytes and removing old red blood cells. A recent mouse study has demonstrated that the phenotype of macrophages in erythroblastic islands is CD169+ VCAM-1+ ER-HR3+ CD11b+ F4/80+ Ly-6G+. Molecular connections between erythroid progenitor cells and central macrophages help to maintain the function and integrity of erythroblastic islands. New research advances in Kruppel-like factor 1 (KLF1) provide new evidence for the important role of macrophages in erythroblastic islands. Macrophages play an important role in erythropoiesis both in sickness and in health, and provide a potential targeted therapy for diseases such as polycythemia vera and beta-thalassemia in the future.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenótipo
/
Fisiologia
/
Molécula 1 de Adesão de Célula Vascular
/
Integrina alfa4beta1
/
Eritropoese
/
Fatores de Transcrição Kruppel-Like
/
Macrófagos
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2016
Tipo de documento:
Artigo
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