Association of TIAM1 gene polymorphisms with Kawasaki disease and its clinical characteristics / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1217-1220, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-279938
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of single nucleotide polymorphisms (SNP) rs22833188 and rs2833195 in TIAM1 gene with the susceptibility to Kawasaki disease (KD) and its clinical characteristic in children.</p><p><b>METHODS</b>A case-control study was performed in this study. One hundred and eighty-eight children with KD and 197 normal children served as controls were enrolled. The genotypes of two SNPs rs22833188 and rs2833195 in TIAM1 gene were detected using PCR-RFLP.</p><p><b>RESULTS</b>There were no significant differences in the genotype (AA, AG and GG) and allele frequencies of SNP rs2833188 between the KD and control groups. Significant differences in the genotype (CC, GC and GG) frequency of SNP rs2833195 were noted between the KD and control groups (P=0.017). The frequency of C allele in the KD group was higher than in the control group (P=0.015). The polymorphism of SNP rs2833188 was associated with the occurrence of rash (P=0.011), and the polymorphism of SNP rs2833195 was associated with the occurrence of conjunctival hyperemia (P=0.021).</p><p><b>CONCLUSIONS</b>The polymorphism of rs2833195 in TIAM1 gene is associated with the susceptibility to KD. The polymorphisms rs2833188 and rs2833195 in TIAM1 gene may be associated with some clinical characteristics in children with KD.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Predisposição Genética para Doença
/
Fatores de Troca do Nucleotídeo Guanina
/
Polimorfismo de Nucleotídeo Único
/
Proteína 1 Indutora de Invasão e Metástase de Linfoma de Células T
/
Genética
/
Genótipo
/
Síndrome de Linfonodos Mucocutâneos
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Lactente
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2015
Tipo de documento:
Artigo
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