No association of -1438G/A polymorphism in promoter region of 5-HT2A receptor gene with antipsychotic agent-induced weight gain / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 575-576, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-279996
ABSTRACT
<p><b>OBJECTIVE</b>To investigate whether the -1438G/A polymorphism in the promoter region of 5-HTR2A gene associates with the weight gain following antipsychotic agents (APS) acute treatment in schizophrenic patients.</p><p><b>METHODS</b>Eighty-four Chinese Han patients with schizophrenia at the first onset were recruited from among 70 nuclear families. The polymorphism of 5-HTR2A gene was determined with PCR-RFLP technique. Body weight was measured in the patients on admission after 10 weeks of treatment with risperidone or chlorpromazine.</p><p><b>RESULTS</b>There were no statistically significant differences in the distribution frequencies of genotype (chi2 0.172, v1, P > 0.05) and allele (chi2 0.121, v1, P > 0.05) of -1438G/A polymorphism of 5-HTR2A gene between subgroups (weight gain >or= 7% or < 7%). Likewise, there was no significant difference in weight gain between genotype groups. By means of transmission disequilibrium test and quantitative transmission disequilibrium test, no significant association between the -1438G/A polymorphism of 5-HTR2A gene and weight gain was observed.</p><p><b>CONCLUSION</b>5-HTR2A gene -1438G/A polymorphism was probably not associated with APS-induced weight gain in Chinese Han patients with schizophrenia in this study.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Esquizofrenia
/
Antipsicóticos
/
Polimorfismo de Fragmento de Restrição
/
Aumento de Peso
/
Clorpromazina
/
Reação em Cadeia da Polimerase
/
Regiões Promotoras Genéticas
/
Risperidona
/
Receptor 5-HT2A de Serotonina
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2005
Tipo de documento:
Artigo
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