Correlation between fibrinogen polymorphisms and the type of cerebral infarction / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 572-574, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-279997
ABSTRACT
<p><b>OBJECTIVE</b>To study the association of beta-fibrinogen(Fg) gene -148 C/T and 448 G/A polymorphisms, plasma Fg concentration, molecular reactivity and the type of cerebral infarction.</p><p><b>METHODS</b>Gene polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism. The plasma Fg concentration and the molecular reactivity were also determined.</p><p><b>RESULTS</b>The Fg concentration in MCI patients with T -148 allele was higher than that in PCI patients and controls. The MCI patients with A448 allele had higher Fg concentration, FMPV and FMPV/Amax when compared with controls, and had higher FMPV/Amax when compared with PCI patients.</p><p><b>CONCLUSION</b>FgB beta -148 and 448 mutational genotypes have impact on Fg concentrationì and therefore increase the risk of MCI.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Sangue
/
Polimorfismo de Fragmento de Restrição
/
Fibrinogênio
/
Infarto Cerebral
/
Reação em Cadeia da Polimerase
/
Predisposição Genética para Doença
/
Genética
/
Genótipo
/
Metabolismo
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2005
Tipo de documento:
Artigo
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