P53 protein expression and chemosensitivity to cisplatin in patients with non-small cell lung cancer: a meta-analysis / 南方医科大学学报
Journal of Southern Medical University
;
(12): 770-773, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-280099
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relation between p53 protein expression and chemosensitivity to cisplatin in patients with non-small cell lung cancer (NSCLC).</p><p><b>METHODS</b>The DerSimonian-Laird random effect model was used to analyze the data reported in relevant literature.</p><p><b>RESULTS</b>Sixteen trials involving 1070 patients were retrieved. The overall positivity rate of p53 was 50.4% and overall response rate to cisplatin was 38.7%. The test for heterogeneity showed that all eligible studies had heterogeneity (chi 2-/+47.57, P<0.0001). The combined odds ratio (OR) was 1.37, with 95% confidence interval of 0.84-2.24.</p><p><b>CONCLUSION</b>Expression of p53 protein in patients with NSCLC is not associated with the chemosensitivity to cisplatin.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Ensaios Clínicos como Assunto
/
Proteína Supressora de Tumor p53
/
Cisplatino
/
Carcinoma Pulmonar de Células não Pequenas
/
Resistencia a Medicamentos Antineoplásicos
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Neoplasias Pulmonares
/
Metabolismo
Tipo de estudo:
Revisões Sistemáticas Avaliadas
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2008
Tipo de documento:
Artigo
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