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Effect of Tongxinluo on the proliferation and differentiation of rat embryonic neural stem cells / 南方医科大学学报
Journal of Southern Medical University ; (12): 679-683, 2008.
Artigo em Chinês | WPRIM | ID: wpr-280122
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of Tongxinluo in on the proliferation and differentiation of rat embryonic neural stem cells (NSCs).</p><p><b>METHODS</b>NSCs were isolated from 12- to 14-day SD rat embryo and treated with Tongxinluo at different doses, and the proliferation and differentiation of the cells were observed by immunofluorescence staining at different time points.</p><p><b>RESULTS</b>The ratio of embryonic NSCs labeled with nestin decreased soon after Tongxinluo treatment, but increased afterwards. Significant difference was noted in the number of cells labeled with beta-tubulin between Tongxinluo group and the control group 3 and 7 days after the treatment, and also between high-dose and low-dose Tongxinluo groups at 7 days.</p><p><b>CONCLUSION</b>Tongxinluo can induce the proliferation and neuronal differentiation of rat embryonic NSCs, and the effect is related to the dose of Tongxinluo administered.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Medicamentos de Ervas Chinesas / Diferenciação Celular / Células Cultivadas / Imunofluorescência / Ratos Sprague-Dawley / Biologia Celular / Proliferação de Células / Relação Dose-Resposta a Droga / Células-Tronco Embrionárias Limite: Animais / Gravidez Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2008 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Medicamentos de Ervas Chinesas / Diferenciação Celular / Células Cultivadas / Imunofluorescência / Ratos Sprague-Dawley / Biologia Celular / Proliferação de Células / Relação Dose-Resposta a Droga / Células-Tronco Embrionárias Limite: Animais / Gravidez Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2008 Tipo de documento: Artigo