Effect of neoadjuvant chemotherapy on ERCC1 gene expression in breast cancer / 南方医科大学学报
Journal of Southern Medical University
;
(12): 603-605, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-280137
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of ERCC1 gene in breast cancer before and after neo-adjuvant chemotherapy.</p><p><b>METHODS</b>The expression of ERCC1 gene was detected by RT-PCR in 40 breast cancer patients and in 14 patients treated with neoadjuvant chemotherapy.</p><p><b>RESULTS</b>Positive expression of ERCC1 gene was detected by RT-PCR in 35.0% of the breast cancer specimens, and ERCC1 expression was not correlated to the patients' age, tumor size, axillary lymph node metastasis, pathological type, histological grade, ER, PR or HER-2 (P>0.05). ERCC1 gene expression was significantly higher in neo-adjuvant chemotherapy group than in non-chemotherapy group (P<0.05).</p><p><b>CONCLUSION</b>The expression of ERCC1 gene does not affect the clinical and pathological features of breast cancer. Neo-adjuvant chemotherapy can increase the expression of ERCC1 gene, due attention should be given to with in subsequent chemotherapy.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias da Mama
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Regulação Neoplásica da Expressão Gênica
/
Carcinoma Ductal de Mama
/
Terapia Neoadjuvante
/
Reação em Cadeia da Polimerase Via Transcriptase Reversa
/
Taxoides
/
Usos Terapêuticos
/
Proteínas de Ligação a DNA
/
Tratamento Farmacológico
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2008
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS