Changes of insulin-like growth factor-I in focal cerebral ischemical reperfusion injury in rats / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To study the changes of insulin-like growth factor-I (IGF-I) in focal cerebral ischemical reperfusion injury model.</p><p><b>METHODS</b>Focal cerebral ischemia was induced in rats using filament method, and the expressions of IGF-I was detected with immunohistochemical staining.</p><p><b>RESULTS</b>The expression of IGF-I was very low in normal brain tissues, but increased in the infracted area and penumbra after cerebral ischemia. The expressions of IGF-I reached the peak level of 14.83-/+0.48 at days 3 after reperfusion.</p><p><b>CONCLUSION</b>Focal cerebral ischemia reperfusion injury enhances the expression of endogenous IGF-I.</p>