Progress of researches on liver-specific transcriptional regulatory sequence / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 443-447, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-280180
ABSTRACT
Gene therapy is a fast developing therapeutics in recent years. Now, the point at issue that restricts the development of gene therapy is the safety and effectivity of gene expression in space, time series and location. Tissular or cellular specific transcriptional regulatory element can make precise and effective expression of exogenous gene in specified tissue and cell, thus increasing the safety and effectivity of gene expression. This has been a hot spot in gene therapy. Now, researches indicate that hepatic tissue has liver-specific transcriptional regulatory sequence. The regulatory sequences can promote gene expression only in hepatic tissue; they are widely used in transgenic animal and gene therapy. They can serve as a basis for the researches in the pathogenic mechanism and gene therapy of liver-related diseases. New achievements in the studies on liver-specific transcriptional regulatory sequence are reviewed in this article.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fatores de Transcrição
/
Transcrição Gênica
/
Terapia Genética
/
Expressão Gênica
/
Regulação da Expressão Gênica
/
Análise de Sequência com Séries de Oligonucleotídeos
/
Elementos Reguladores de Transcrição
/
Redes Reguladoras de Genes
/
Genética
/
Fígado
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2009
Tipo de documento:
Artigo
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