Molecular Mechanism of Action of hnRNP K and RTN3 in the Replication of Enterovirus 71 / 病毒学报
Chinese Journal of Virology
;
(6): 197-200, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-280273
ABSTRACT
Enterovirus 71 (EV71) is a neurotropic pathogen that can induce hand, foot and mouth disease in children. There is an appreciable mortality rate after EV71 infections. The mechanism of action of EV71 replication is not known. Recent work has identified some of cell factors of the host that participate in the synthesis of the RNA and proteins of EV71 (e.g., hnRNP K, reticulon 3 (RTN 3)). In that work, researchers used a competitive assay to show that hnRNP K can interact with EV71 5' UTR, which is required for efficient synthesis of viral RNA. Using a yeast two-hybrid system, other researchers demonstrated that RTN 3 interacts with the N-terminal domain of EV71 2C, which is crucial for replication of viral RNA. Here, we discuss recent work focusing on the molecular mechanisms of hnRNP K and RTN 3 in the synthesis of the RNA and proteins of EV71.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Ribonucleoproteínas
/
Proteínas Virais
/
Virologia
/
Replicação Viral
/
Proteínas de Transporte
/
Enterovirus Humano A
/
Ribonucleoproteínas Nucleares Heterogêneas Grupo K
/
Infecções por Enterovirus
/
Interações Hospedeiro-Patógeno
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Virology
Ano de publicação:
2015
Tipo de documento:
Artigo
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