Preliminary study of a universal vaccine based on the HA2 protein of the H5N1 influenza virus / 病毒学报
Chinese Journal of Virology
;
(6): 521-528, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-280333
ABSTRACT
Fragments encoding amino acids 76-130 in the linear conserved region (LCR) of A/Hubei/1/2010 (H5N1) HA2 was fused to hepatitis B core antigen (HBc) to generate a LCR-HBe virus-like particle (VLP). Results showed that the fusion protein of LCR-HBc was highly expressed in this prokaryotic expression system. The purified LCR-HBc particle stimulated high levels of IgG production in mice with a titer of > 112 800, and provided 50% cross-protection against lethal challenge by H1N1 viruses.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Dados de Sequência Molecular
/
Vacinas contra Influenza
/
Sequência de Aminoácidos
/
Interferon gama
/
Glicoproteínas de Hemaglutininação de Vírus da Influenza
/
Alergia e Imunologia
/
Virus da Influenza A Subtipo H5N1
/
Pulmão
/
Camundongos Endogâmicos BALB C
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Virology
Ano de publicação:
2014
Tipo de documento:
Artigo
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