Recent progress in interferon induced protein GBP1 research / 病毒学报
Chinese Journal of Virology
; (6): 456-462, 2014.
Article
em Zh
| WPRIM
| ID: wpr-280343
Biblioteca responsável:
WPRO
ABSTRACT
Guanylate-binding protein 1 (GBP1) is an interferon induced protein, that belongs to the guany late-binding protein family. GBP1 is widely involved in anti-infection immune responses, anti-tumor activity and various biological reactions. Recent studies have proved that IFN-alpha, IFN-beta, IFN-gamma, IL1alpha, IL1beta, TNF-alpha and LPS can induce GBP1 expression; hence, the diverse biological functions of GBP1 have been gradually deduced and exploited. Many studies have been performed over recent years to understand the exact mechanisms that underlie the anti-infection and anti-tumor properties of GBP1. This review describes the molecular structure, biological activity, anti-infective properties and other functions of GBP1, in order to provide insights into the divergent roles of GBP1 in the regulation of various biological processes.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Antivirais
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Química
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Interferons
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Proteínas de Ligação ao GTP
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Genética
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Metabolismo
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Antineoplásicos
Limite:
Animals
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Humans
Idioma:
Zh
Revista:
Chinese Journal of Virology
Ano de publicação:
2014
Tipo de documento:
Article