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ZAP-70 expression in 24 patients with B cell chronic lymphocytic leukemia / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 237-240, 2006.
Artigo em Chinês | WPRIM | ID: wpr-280693
ABSTRACT
To explore the ZAP-70 expression in chronic lymphocytic leukaemia (CLL) and its relationship with other prognostic factors, the expressions of ZAP-70 protein and CD38 in bone marrow or peripheral blood of 24 patients with B-CLL were determined by four-color flow cytometry. The results showed that ZAP-70 was positively expressed in 37.5% of all B-CLL patients, 20% (3/15) patients in Binet A stage, and 66.7% in Binet B + C. The expression of ZAP-70 had significant difference between Binet A and Binet B + C (P < 0.05). CD38 was expressed in 29.1% of B-CLL patients and 3 out of these cases were in stage A, 2 out of 3 cases in stage A co-expressed CD38 and ZAP-70. The expression of CD38 had no significant difference between Binet A and Binet B + C stage (P > 0.05). ZAP-70+ and CD38+ were both expressed in 83.3% of B-CLL patients (P < 0.05). It is concluded that ZAP-70 protein can be routinely measured by flow cytometry in the laboratory. High expression of ZAP-70 is correlated with other prognostic factors such as clinic stage, chromosome abnormalities and CD38 in B-CLL.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prognóstico / Leucemia Linfocítica Crônica de Células B / ADP-Ribosil Ciclase 1 / Proteína-Tirosina Quinase ZAP-70 / Citometria de Fluxo / Genética / Metabolismo Tipo de estudo: Estudo prognóstico Limite: Adulto / Idoso / Aged80 / Humanos / Masculino Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prognóstico / Leucemia Linfocítica Crônica de Células B / ADP-Ribosil Ciclase 1 / Proteína-Tirosina Quinase ZAP-70 / Citometria de Fluxo / Genética / Metabolismo Tipo de estudo: Estudo prognóstico Limite: Adulto / Idoso / Aged80 / Humanos / Masculino Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2006 Tipo de documento: Artigo