Thrombin and angiogenesis of cancer--review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 197-200, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-280702
ABSTRACT
Thrombin is the most important factor in hemostasis. In recent years, it has been found that thrombin is a potent mitogen capable of inducing cellular functions. Therefore, it is proved to be of importance in promoting the growth, metastasis and angiogenesis of cancer. Anticoagulant therapy not only reduce the characteristic hypercoagulability of cancer, but also inhibits growth and metastasis of cancer, and alters the fundamental biology of cancer. In this paper thrombin and its receptor, relationship of thrombin and its receptor with cancer growth, metastasis and angiogenesis, the mechanisms of thrombin influence on cancer angiogenesis, as well as application prospects on anti-angiogenesis and anti-coagulation therapy were reviewed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Trombina
/
Antitrombinas
/
Receptores de Trombina
/
Inibidores da Angiogênese
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Anticoagulantes
/
Neoplasias
/
Neovascularização Patológica
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2006
Tipo de documento:
Artigo
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