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Progress in the study of lyophilization of human red blood cells--review / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 191-196, 2006.
Artigo em Chinês | WPRIM | ID: wpr-280703
ABSTRACT
Now the clinical preservation methods of human red blood cells mainly include hypothermic storage (4 degrees C) and cryopreservation (-80 degrees C or -196 degrees C). The preservation time of hypothermic storage of red blood cells is relatively short and it is easy to be contaminated by microbes. Cryopreservation greatly prolongs the storage time, but it needs heavy storage equipments. Because the protective solutions in cryopreservation contain glycerol, red blood cells need complicated washing in order to remove glycerol. These shortage methods limit their application to some special conditions, such as war or natural disasters. Compared with conventional preservation methods of red blood cells, lyophilization has many advantages such as less weight, convenient transportation, room temperature preservation, prone to be rehydrated. In this review, the progress and challenge in the development of lyophilization of red blood cells, especially application of trehalose and its mechanism in the lyophilization of red blood cells were systematically discussed. This review can provide some theoretic guidance for developing a safe, simple and efficient preservation approach of red blood cells by lyophilization.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Trealose / Preservação de Sangue / Criopreservação / Eritrócitos / Liofilização Tipo de estudo: Guia de Prática Clínica Limite: Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Trealose / Preservação de Sangue / Criopreservação / Eritrócitos / Liofilização Tipo de estudo: Guia de Prática Clínica Limite: Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2006 Tipo de documento: Artigo