Detection of MRD and its clinical application--review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1131-1136, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-280751
ABSTRACT
With recent development and progress achieved in the diagnosis and treatment of leukemia, relapse of disease still remains as the major problem in clinical management and the minimal residual disease (MRD) has been confirmed to be associated with leukemia relapse in the past decades. Due to the low sensitivity, morphology-based assays have limitation in the MRD monitoring. With the development of molecular assays, especially the real-time RT-PCR method have been a sensitive, precise and reliable tool to MRD detection. Numerous clinical studies demonstrated that the existence of MRD reflects the clinical and molecular response, and remain as a major prognostic factor for leukemia. Another important application of MRD detection is to evaluate the efficacy of different therapy at molecular level. In this paper, the different methods and their clinical application for MRD detection were systemically reviewed and it is confident that the establishment of standardized MRD detection system will be important in the clinical prevention for relapse of leukemia.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Leucemia
/
Imunofenotipagem
/
Sensibilidade e Especificidade
/
Neoplasia Residual
/
Reação em Cadeia da Polimerase Via Transcriptase Reversa
/
Diagnóstico
/
Alergia e Imunologia
/
Citometria de Fluxo
/
Genética
/
Métodos
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2005
Tipo de documento:
Artigo
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