Study of biological safety of scaffold material with heterologous deproteinized bone / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 234-237, 2006.
Artigo
em Inglês
| WPRIM
| ID: wpr-280905
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the biological safety of manufactured heterologous deproteinized bone and to provide an experimental basis for clinical applications.</p><p><b>METHODS</b>Deproteinized bone (10 mm) and leaching liquor were made from pig ribs with a series of physical and chemical methods, then were evaluated through acute and subacute toxicity test, hemolysis test, pyrogen test, intracutaneous test, intramuscular implantation test and cytotoxity test.</p><p><b>RESULTS</b>No obvious toxicity, hemolysis, pyrogenic characteristics, skin irritation, inflammatory reaction after intramuscular implantation and cytotoxity were observed.</p><p><b>CONCLUSIONS</b>The heterologous deproteinized bone has good biological safety and meets all the demands of scaffold material for tissue engineering.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transplante Heterólogo
/
Testes Imunológicos de Citotoxicidade
/
Transplante Ósseo
/
Engenharia Tecidual
/
Hemólise
Limite:
Animais
Idioma:
Inglês
Revista:
Chinese Journal of Traumatology
Ano de publicação:
2006
Tipo de documento:
Artigo
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