Effects of seawater immersion on the functions of mitochondria of myocardium and hepatocyte in hemorrhagic shock rats / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 38-42, 2006.
Artigo
em Inglês
| WPRIM
| ID: wpr-280940
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of seawater immersion on the function of myocardium and hepatocyte mitochondria in experimental hemorrhagic shock rats.</p><p><b>METHODS</b>Twenty-four male Wistar rats were divided into three groups (n=8 in each group) control group, HSL group (hemorrhagic shock group on land) and HSS group (hemorrhagic shock group in seawater). The hemodynamic parameters, activities of H(+)-ATPase (adenosinetriphosphatase), succinate dehydrogenase (SDH) and Ca(2+)-Mg(2+)-ATPase, the calcium contents in myocardium and hepatocyte mitochondria were measured and the changes of proton translocation across the inner mitochondrial membrane were analyzed.</p><p><b>RESULTS</b>The hemodynamic indexes and the activities of H+-ATPase, SDH, Ca(2+)-Mg(2+)-ATPase in HSS group were significantly lower than those in control group and HSL group (P<0.05). In HSS group the calcium levels in tissue and mitochondria of myocardium and hepatocyte were elevated significantly compared with control group and HSL group (P<0.05). There was no significant difference in proton translocation among three groups.</p><p><b>CONCLUSIONS</b>This investigation demonstrates that seawater immersion can aggravate the conditions of hemorrhagic shock rats.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Água do Mar
/
Choque Hemorrágico
/
Mitocôndrias Hepáticas
/
Distribuição Aleatória
/
Cálcio
/
Ratos Wistar
/
ATPases Translocadoras de Prótons
/
Imersão
/
Metabolismo
/
Mitocôndrias Cardíacas
Limite:
Animais
Idioma:
Inglês
Revista:
Chinese Journal of Traumatology
Ano de publicação:
2006
Tipo de documento:
Artigo
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