Preparation of water-soluble chitosan solid dispersion of daidzein / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 293-296, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-281032
ABSTRACT
<p><b>OBJECTIVE</b>To enhance the dissolution rate of daidzein with solid dispersion technique.</p><p><b>METHOD</b>Solid dispersions were prepared by the solvent method using water-solubility chitosan as a hydrophilic carrier. DSC, IR and X-ray methods were used to verify the formation of solid dispersion.</p><p><b>RESULT</b>Dissolution percentages of solid dispersions were more than 90 percent in the drug-carrier ratio of 15 and 19. But dissolution percentages of physical mixtures and pure drug were 40 and 38.4 percent respectively. Part of daidzein dispersed in solid dispersion in the form of microcrystalline.</p><p><b>CONCLUSION</b>Water-soluble chitosan solid dispersion can significantly increase dissolution rate of daidzein.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Solubilidade
/
Espectrofotometria Infravermelho
/
Difração de Raios X
/
Varredura Diferencial de Calorimetria
/
Água
/
Química
/
Quitosana
/
Isoflavonas
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2010
Tipo de documento:
Artigo
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