Collection of a Chinese pedigree with Parkinson's disease and linkage analysis of nine susceptibility genes / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 368-371, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-281196
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the susceptibility genes of a Parkinson's Disease (PD) family.</p><p><b>METHODS</b>The blood samples of a four-generation classic idiopathic PD family were collected. Two-point LOD score method was applied to analyze the linkage disequilibrium between the disease locus and microsatellite markers.</p><p><b>RESULTS</b>We studied 13 markers near the 9 genes that had been reported to be associated with PD. No obvious evidence showed that the selected markers had anything correlation with PD locus.</p><p><b>CONCLUSION</b>These 9 genes are not the susceptibility genes of PD in this family.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doença de Parkinson
/
Linhagem
/
China
/
Repetições de Microssatélites
/
Predisposição Genética para Doença
/
Genética
/
Genótipo
/
Ligação Genética
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2006
Tipo de documento:
Artigo
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