Your browser doesn't support javascript.
loading
Steroid Response in Refractory Asthmatics
The Korean Journal of Internal Medicine ; : 143-148, 2012.
Artigo em Inglês | WPRIM | ID: wpr-28120
ABSTRACT
Inhaled glucocorticosteroids are currently the most effective anti-inflammatory controller medications for treating persistent asthma. The efficacies of glucocorticoids include reducing asthma symptoms, reducing exacerbation frequency, improving quality of life, improving lung function, decreasing airway hyperresponsiveness, controlling airway inflammation, and reducing mortality. However, the treatment response to glucocorticosteroids in asthmatics varies, and certain subtypes of asthma, such as refractory asthma, respond poorly to high-dose inhaled glucocorticoid and systemic steroids. The medical costs of treating refractory asthmatics represent about 50% of the total healthcare cost for asthma. A thorough understanding of the mechanisms of glucocorticoid action, patient responses to glucocorticoids, and steroid resistance observed in refractory asthmatics is necessary for the targeted development of therapeutic drugs. This review discusses the characteristics of severe refractory asthmatics and the mechanisms of steroid response and resistance in asthma treatment.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Asma / Índice de Gravidade de Doença / Administração por Inalação / Resistência a Medicamentos / Resultado do Tratamento / Antiasmáticos / Glucocorticoides / Pulmão / Anti-Inflamatórios Limite: Humanos Idioma: Inglês Revista: The Korean Journal of Internal Medicine Ano de publicação: 2012 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Asma / Índice de Gravidade de Doença / Administração por Inalação / Resistência a Medicamentos / Resultado do Tratamento / Antiasmáticos / Glucocorticoides / Pulmão / Anti-Inflamatórios Limite: Humanos Idioma: Inglês Revista: The Korean Journal of Internal Medicine Ano de publicação: 2012 Tipo de documento: Artigo