Frequencies distribution of human leukocyte antigen-B27 subtypes in healthy Chinese / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 240-243, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-281224
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the frequencies distribution of human leukocyte antigen (HLA)-B27 subtypes in unrelated healthy Chinese.</p><p><b>METHOD</b>Polymerase chain reaction sequence-based typing (PCRSBT) was used to determine HLA high-resolution genotypes of 825 unrelated healthy Chinese.</p><p><b>RESULTS</b>A total of 25 HLA-B27-positive individuals and 8 HLA-B27 subtypes were detected. These subtypes and their corresponding frequencies were B * 2704 (30.77%) , B * 2705 (23.08%), B * 2707 (19.23%), B * 2711 (7.69%), B * 2712 (7.69%), B * 2701 (3.85%), B * 2713 (3.85%) and B * 2721 (3.85%).</p><p><b>CONCLUSION</b>The data obtained through PCR-SBT method may serve as important reference for the research of relationship between HLA-B27 subtypes and some diseases such as ankylosing spondylitis.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Espondilite Anquilosante
/
Antígeno HLA-B27
/
Reação em Cadeia da Polimerase
/
Classificação
/
Análise de Sequência de DNA
/
Predisposição Genética para Doença
/
Povo Asiático
/
Frequência do Gene
/
Genética
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2006
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS