Myopathy due to Chronic Clevudine Therapy: A Case Report
Korean Journal of Pathology
;
: 575-579, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-28151
ABSTRACT
A 40-year-old man with chronic hepatitis B complained of progressive weakness of the proximal muscles and edema of both legs. He had been receiving long-term clevudine (nucleoside analogue reverse transcriptase inhibitor, NRTI) therapy for his hepatitis. The serum creatine kinase level was increased on the laboratory tests. His electromyography showed a generalized myopathic process. The muscle biopsy showed numerous ragged-red fibers, degenerating myofibers with variable sized cytoplasmic bodies, the prominence of type 1 fibers with type 2 fiber atrophy and an endomysial mononuclear cell infiltration. The electron microscopic examination revealed necrotic myofibers, including extremely dysmorphic mitochondria with extensive loss, blunting and focal clumping of the cristae and concentric cristae. Although clevudine is known to be a less cytotoxic agent among the various NRTIs, careful clinical attention should be paid to the patients who are receiving long-term clevudine therapy for the occurrence of myopathy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Arabinofuranosiluracila
/
Atrofia
/
Biópsia
/
DNA Polimerase Dirigida por RNA
/
Miopatias Mitocondriais
/
Hepatite B Crônica
/
Creatina Quinase
/
Citoplasma
/
Edema
/
Eletromiografia
Limite:
Adulto
/
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Pathology
Ano de publicação:
2009
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS