Impact of fenofibrate on NO and endothelial VCAM-1 expression in hyperlipidemic rats / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1872-1874, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-281517
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the mechanism of hyperlipidemia- and imflammation-induced functional impairment of the endothelium.</p><p><b>METHODS</b>The experiment was conducted using 3 groups of rats fed for 20 weeks with standard chow (control group), high-fat diet and high-fat diet with daily fenofibrate treatment (10 mg/kg, starting since the fifth week), respectively. After 4 and 20 weeks of feeding, respectively, serum lipid level and NO concentration were measured in the rats, and the epithelial vascular cell adhesion molecule-1 (VCAM-1) expression and cell adhesiveness to the aortic endothelium were observed.</p><p><b>RESULTS</b>Compared with the control group, the rats with hyperlipidemia induced by long-term high-fat diet feeding showed lower NO concentration and increased leukocyte accumulation on the endothelial surface, exhibiting also stronger and more extensive endothelial expression of VCAM-1. In contrast, the hyperlipidemic rats with fenofibrate treatment shoed significantly decreased VCAM-1 expression and leukocyte adhesion with recovery of the NO level.</p><p><b>CONCLUSION</b>NO deficiency and activation of inflammation are involved in vascular impairment in rats with high-fat diet-induced hyperlipidemia, and fenofibrate can effectively prevent atherosclerosis by restoring NO concentration and down-regulating VCAM-1 expression in these rats.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Fenofibrato
/
Endotélio Vascular
/
Adesão Celular
/
Ratos Sprague-Dawley
/
Molécula 1 de Adesão de Célula Vascular
/
Biologia Celular
/
Tratamento Farmacológico
/
Aterosclerose
/
Hiperlipidemias
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2007
Tipo de documento:
Artigo
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