Effect of enalapril on diabetic rat myocardial ultrastructure / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To observe the changes in the myocardial ultrastructure of diabetic rats and the effect of enalapril treatment.</p><p><b>METHODS</b>Male Wistar rats were divided into 3 groups, namely the control group, diabetic group and enalapril intervention group. Diabetes was induced with peritoneal injection of streptozotocin in the latter 2 groups, and in enalapril group, the rats were treated with enalapril at the daily oral dose of 2 mg/kg for 1, 3 and 5 months after streptozotocin injection. Histological analysis of the left ventricular tissue was performed with transmission electron microscope 1, 3, and 5 months after establishment of diabetes.</p><p><b>RESULTS</b>Onset of myocardial damages was observed 1 month after the development of diabetes in the rats with gradual time-dependent exacerbation. Enalapril treatment could partially reverse the myocardial destruction in the diabetic rats.</p><p><b>CONCLUSION</b>Enalapril intervention may improve the ultrastructural pathology of the myocardium in diabetic rats, which is suggestive of the action mechanisms of angiotensin-converting enzyme inhibitors in myocardium preservation.</p>