Preparation of gemcitabine polybutylcyanoacrylate nanoparticles / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1653-1656, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-281570
ABSTRACT
<p><b>OBJECTIVE</b>To optimize the preparation process of gemcitabine polybutylcyanoacrylate nanoparticles (GCTB- PBCA-NP).</p><p><b>METHODS</b>According to the particle size, the entrapment efficiency and the loading quantity of GCTB-PBCA-NP, single factor analysis was carried out to optimize the component composition and preparation process based on an orthogonal design.</p><p><b>RESULTS</b>The mean particle size of the NP was (112-/+9) nm with an entrapment efficiency of (54.12-/+2.43)% and drug loading of (11.08-/+0.89)%.</p><p><b>CONCLUSION</b>An optimized nanoparticular drug delivery system is obtained by emulsion polymerization.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Química
/
Química Farmacêutica
/
Sistemas de Liberação de Medicamentos
/
Desoxicitidina
/
Embucrilato
/
Nanopartículas
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2007
Tipo de documento:
Artigo
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