Antidysmenorrheic effects of Radix angelica and Rhizoma Chuanxiong with different proportions and preparation methods on dysmenorrhea model mice / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 892-895, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-281692
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Radix Angelica and Rhizoma Chuanxiong with different proportions (1 0, 2 1, 1.5 1, 1 1, 1 1.5, 1 2, 0 1), different extraction in order (by water, by ethanol, firstly by alcohol then by water) on dysmenorrhea model mice in order to observe their compatibility rules and material foundation.</p><p><b>METHOD</b>The mice model of primary dysmenorrhea was used to study the effect of Radix Angelica and Rhizoma Chuanxiong with different proportions and preparation methods on writhing response and the levels of nitric oxide and calcium ion in mice uterine tissue.</p><p><b>RESULT</b>Danggui-Chuanxiong (1. 5 1) and solution extracted firstly by alcohol then by water showed the strongest effect on primary dysmenorrhea by reducing the writhing times, increasing nitric oxide (NO) concentration and reducing calcium ion (Ca2+) concentration in uterine tissue.</p><p><b>CONCLUSION</b>Radix Angelica and Rhizoma Chuanxiong with different proportions and preparation methods showed different antidysmenorrheic trend on dysmenorrhea model mice, which was related with the containing constituents.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Útero
/
Comportamento Animal
/
Medicamentos de Ervas Chinesas
/
Química
/
Química Farmacêutica
/
Cálcio
/
Apiaceae
/
Rizoma
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2010
Tipo de documento:
Artigo
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